Clinical Effects of Nifedipine Combined with Magnesium Sulfate in the Treatment of Hypertensive Disorders of Pregnancy and Its Impact on Uterine Artery Blood Flow
Objective To investigate the clinical effects of nifedipine combined with magnesium sulfate in the treatment of hypertensive disorders of pregnancy(HDP)and its impact on uterine artery blood flow.Methods Eighty patients with HDP treated at Xihua County People's Hospital from January 2020 to December 2023 were selected and randomly divided into a study group(n=40)and a control group(n=40)using a random number table.The control group was treated with nifedipine,while the study group was treated with nifedipine combined with magnesium sulfate.The clinical efficacy,blood pressure levels,uterine artery blood flow,maternal and infant outcomes,and adverse reactions were compared between the two groups.Results The treatment efficacy in the study group(92.50%)was higher than that in the control group(75.00%),with a statistically significant difference(P＜0.05).After treatment,the diastolic blood pressure(DBP)and systolic blood pressure(SBP)levels in both groups decreased,with the study group showing lower levels than the control group,and the differences were statistically significant(P＜0.05).After treatment,the resistance index(RI),pulsatility index(PI),and systolic/diastolic ratio(S/D)in both groups decreased,with the study group showing lower levels than the control group,and the differences were statistically significant(P＜0.05).The incidence of adverse maternal and infant outcomes in the study group(40.00%)was lower than that in the control group(75.00%),with a statistically significant difference(P＜0.05).The incidence of adverse reactions in the study group(62.50%)was not significantly different from that in the control group(67.50%)(P＞0.05).Conclusion The combination of nifedipine and magnesium sulfate in the treatment of HDP can improve clinical efficacy,lower blood pressure levels,improve uterine artery blood flow and maternal and infant outcomes,without increasing adverse reactions.
hypertensive disorders of pregnancynifedipinemagnesium sulfateuterine artery blood flow
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