Observation on the Therapeutic Effect of Budesonide Inhalation Aerosol on Chronic Obstructive Pulmonary Disease
Objective To observe the therapeutic effect of Budesonide inhalation aerosol on patients with chronic obstructive pulmonary disease(COPD).Methods The research subjects were 72 patients with COPD treated in The Second Affiliated Hospital of Zhengzhou University from July 2021 to July 2023.They were divided into a reference group(treated with Budesonide)and an intervention group(treated with Budesonide inhalation aerosol)by random drawing,with 36 cases in each group.The therapeutic effects of the two groups were compared and analyzed.Results Before treatment,there was no statistical significance in the comparison of clinical indicators between the two groups(P＞0.05).After treatment,the arterial carbon dioxide tension(PaCO2)and the frequency of respiration and heart rate in the intervention group were lower than those in the reference group,and the arterial partial pressure of oxygen(PaO2)was higher than that in the reference group,with statistically significant differences(P＜0.05).Before treatment,there was no statistical significance in the comparison of lung function indicators between the two groups(P＞0.05).After treatment,the peak expiratory flow rate(PEF),forced expiratory volume in the first second(FEV1),forced vital capacity(FVC),FEV1/FVC,and vital capacity(VC)indicators of the intervention group were all higher than those of the reference group,with statistically significant differences(P＜0.05).Before treatment,there was no statistical significance in the comparison of inflammatory indicators between the two groups(P＞0.05).After treatment,the levels of serum amyloid A(SAA)and C-reactive protein(CRP)in the intervention group were lower than those in the reference group,with statistically significant differences(P＜0.05).Before treatment,there was no statistical significance in the comparison of the Quality of Life Inventory(QOL-I)and Medical Research Council Dyspnea Scale(MRC)scores between the two groups(P＞0.05).After treatment,the QOL-I score of the intervention group was higher than that of the reference group,and the MRC score was lower than that of the reference group,with statistically significant differences(P＜0.05).Conclusion The treatment of COPD patients with Budesonide inhalation aerosol is significantly effective.It can improve blood oxygen and lung function,improve the body's inflammatory response,alleviate dyspnea and improve quality of life,and is worth applying in clinical practice.
chronic obstructive pulmonary diseaseinflammatory indicatorslung functionbudesonidequality of life
万方数据
维普
