Clinical Efficacy of Methimazole Tablets Combined with Propranolol in the Treatment of Hyperthyroidism
Objective To explore the clinical efficacy of methimazole tablets combined with propranolol in the treatment of hyperthyroidism.Methods From September 2020 to September 2022,102 patients with hyperthyroidism treated in the General Hospital of Yima Coal Industry Group Co.,Ltd.were selected.They were divided into a control group(methimazole tablets)and an observation group(methimazole tablets combined with propranolol)with 51 cases each using a random number table method.The treatment effectiveness,thyroid function,inflammatory factors,lipid metabolism indicators,and adverse reaction incidence rate of the two groups were compared.Results The treatment effectiveness rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the thyroid-stimulating hormone(TSH)of both groups increased compared to those before treatment,and the thyroid-stimulating hormone receptor antibody(TRAb),free triiodothyronine(FT3),and free thyroxine(FT4)decreased compared to those before treatment,and the difference was statistically significant(P＜0.05);after treatment,the TSH of the observation group was higher than that of the control group,and TRAb,FT3,and FT4 were lower than those of the control group,and the difference was statistically significant(P＜0.05).After treatment,the interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),and transforming growth factor-β1(TGF-β1)of both groups decreased compared to those before treatment,and the difference was statistically significant(P＜0.05);after treatment,the IL-8,TNF-α,and TGF-β1 of the observation group were lower than those of the control group,and the difference was statistically significant(P＜0.05).After treatment,the total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)of both groups increased compared to those before treatment,and the difference was statistically significant(P＜0.05);after treatment,the TC,TG,HDL,and LDL of the observation group were higher than those of the control group,and the difference was statistically significant(P＜0.05).The incidence rate of adverse reactions in the control group was higher than that in the observation group,and the difference was statistically significant(P＜0.05).Conclusion The treatment of hyperthyroidism patients with methimazole tablets combined with propranolol has a significant effect,can improve thyroid function,increase blood lipid levels,reduce inflammatory response,and reduce the incidence of adverse reactions.
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