Clinical Study on the Treatment of Threatened Preterm Labor with Magnesium Sulfate and Phenol
Objective To analyze the application effect of magnesium sulfate and phloroglucinol in the treatment of threatened preterm labor.Methods The general data of 62 patients with threatened preterm labor treated in Luoyang Petrochemical Hospital from June 2020 to September 2023 were retrospectively analyzed.According to different treatment methods,they were divided into a reference group and a research group,each with 31 cases,treated with magnesium sulfate and phenol respectively.The treatment effectiveness,full-term delivery rate,clinical related indicators(pregnancy prolongation time,contraction disappearance time),neonatal outcomes(neonatal asphyxia rate,low birth weight rate,Apgar score),inflammatory factor levels[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-alpha(TNF-α)],and adverse reaction incidence rate of the two groups of patients were compared.Results The treatment efficacy in the study group(93.55%)was higher than that in the reference group(70.97%),and the full-term delivery rate(83.87%)was higher than that in the reference group(61.29%),with statistically significant differences(P＜0.05).The clinical related indicators and neonatal outcomes of the two groups showed statistically significant differences(P＜0.05).The disappearance time of contractions in the study group was shorter than that in the reference group,the prolongation of pregnancy was longer than that in the reference group,and the neonatal asphyxia rate(6.45%)and low birth weight rate(9.68%)were lower than those in the reference group(25.81%,32.26%),with higher Apgar scores,all showing statistically significant differences(P＜0.05).There were no statistically significant differences in IL-6,CRP,and TNF-α levels between the two groups before treatment(P＞0.05).However,7 days after treatment and at the end of treatment,the levels of these indicators in the study group were lower than those in the reference group,with statistically significant differences(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the reference group,with statistically significant differences(P＜0.05).Conclusion Compared with magnesium sulfate,phenol is more conducive to improving the full-term delivery rate,reducing the level of inflammatory factors,shortening the contraction disappearance time,delaying pregnancy time,and improving the clinical outcome of the child.
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