Observation on the Efficacy of Different Doses of Recombinant Human Growth Hormone in the Treatment of Patients with Idiopathic Short Stature
Objective To observe the effect of different doses of recombinant human growth hormone(rhGH)in the treatment of children with idiopathic short stature(ISS).Methods 61 children with ISS admitted to The First Affiliated Hospital of Henan University of Science and Technology from February 2021 to July 2023 were included.All patients received rhGH treatment.According to different doses of rhGH treatment,they were divided into three groups:low-dose group(20 cases,0.26 mg/kg),medium-dose group(20 cases,0.35 mg/kg),and high-dose group(21 cases,0.41 mg/kg).The height,annual growth rate,and related blood test indicators of children in different groups were observed.Results Before treatment and 3 months after treatment,there was no statistical significance in the comparison of height among the three groups of children(P＞0.05).Six months after treatment,the height of children in the high-dose group was higher than that in the low-dose and medium-dose groups,with a statistically significant difference(P＜0.05).Before treatment,there was no statistical significance in the comparison of annual growth rate among the three groups(P＞0.05).Three months and six months after treatment,the annual growth rate of the high-dose group was higher than that of the low-dose and medium-dose groups,with a statistically significant difference(P＜0.05).Before treatment,there was no statistical significance in the comparison of blood glucose levels among the three groups(P＞0.05).Three months after treatment,the blood glucose level of the high-dose group was higher than that of the low-dose and medium-dose groups,with a statistically significant difference(P＜0.05).Six months after treatment,the blood glucose level of the high-dose group was higher than that of the medium-dose group and lower than that of the low-dose group,with a statistically significant difference(P＜0.05).Before treatment,3 months and 6 months after treatment,there was no statistical significance in the comparison of serum free triiodothyronine(FT3),serum free thyroxine(FT4),and thyroid-stimulating hormone(TSH)levels among the three groups(P＞0.05).Conclusion High-dose rhGH treatment has a significant effect on ISS,and it increases the patient's fasting blood glucose level during treatment.Therefore,during high-dose rhGH treatment,the above two indicators of children need to be closely monitored.
recombinant human growth hormoneidiopathic short staturegrowth parameters
万方数据
维普
