The Significance of Immunohistochemical Detection in the Pathological Diagnosis of Breast Cancer
Objective To explore the significance of immunohistochemical detection in the pathological diagnosis of breast cancer.Methods 80 cases of breast cancer patients treated in Xuchang Hospital from January 2021 to January 2023 were selected as the observation group,and another 80 cases of benign breast tumor patients in the same period were selected as the control group.The breast cancer tissues and benign tumor tissues were subjected to immunohistochemical detection of estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER-2)positive expression,and the correlation between the clinical pathological characteristics of breast cancer patients and the positive expression rate of ER,PR,and HER-2 was analyzed.Results The positive expression rates of ER,PR,and HER-2 in the observation group(76.25%,75.00%,72.50%)were significantly higher than those in the control group(30.00%,26.25%,31.25%),with statistically significant differences(P＜0.05).In breast cancer tissues,the positive expression rates of ER,PR,and HER-2 in different clinical stages,muscle layer infiltration,lymph node metastasis,and histological differentiation were compared,and the differences were statistically significant(P＜0.05).The clinical stage,muscle layer infiltration,lymph node metastasis,and histological differentiation of breast cancer patients were positively correlated with the positive expression rate of ER,PR,and HER-2,with statistically significant differences(P＜0.05).Conclusion Breast cancer patients often have positive expression of ER,PR,and HER-2,which is related to the clinical pathological characteristics of the patients.Immunohistochemical detection can provide a basis for pathological diagnosis.
breast cancerimmunohistochemical detectionpathological diagnosishuman epidermal growth factor receptor 2correlation
万方数据
维普
