Evaluation of the Screening Value of TgAb,TPOAb Combined with Five Thyroid Function Tests in Graves'Disease during Pregnancy
Objective To explore the screening value of the combined detection scheme of thyroid globulin antibody(TgAb),serum thyroid peroxidase antibody(TPOAb),and five thyroid function tests[thyroxine(T4),triiodothyronine(T3),thyroid-stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4)]in Graves'disease during pregnancy.Methods 100 pregnant women who underwent pregnancy tests and had Graves'disease admitted to The Third People's Hospital of Anyang City from August 2021 to August 2023 were selected as the disease group.Another 100 healthy pregnant women who underwent physical examinations during the same period were selected as the healthy group.The levels of TgAb,TPOAb,T4,T3,TSH,FT3,and FT4 in the two groups were compared.Results The levels of TgAb,TPOAb,FT3,and FT4 in the disease group were higher than those in the healthy group,while the levels of T3,T4,and TSH were lower than those in the healthy group,with statistically significant differences(P＜0.05).The area under the curve(AUC)of TgAb for the diagnosis of Graves'disease during pregnancy was 0.685,which was lower than that of TPOAb(0.715)and the five thyroid function tests(0.816).The AUC of the combined detection of TgAb,TPOAb,and the five thyroid function tests was 0.852,which was superior to the individual detection of each indicator,with statistically significant differences(P＜0.05).Conclusion The combined detection of TgAb,TPOAb,and the five thyroid function tests in patients with Graves'disease during pregnancy can obtain good diagnostic value.
万方数据
维普
