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血脂异常患者载脂蛋白B代谢水平与血脂指标的相关性研究

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目的 探究血脂异常患者载脂蛋白B代谢水平与血脂指标的相关性。方法 选取新乡市中心医院新乡医学院第四临床学院 2021 年 10 月至 2022 年 10 月期间收入 150 例血脂异常患者为研究组,依据血脂异常类型分为高胆固醇血症、高甘油三酯血症、混合型高脂血症、低高密度脂蛋白血症,同期选择体检健康者 150 例作为对照组,均开展总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白B(ApoB)检测,分析研究组、对照组的血脂相关指标;检测分析结果并探讨载脂蛋白B与其他指标的相关性。结果 研究组LDL-C、TG、TC、ApoB指标高于对照组,而HDL-C指标低于对照组,差异均有统计学意义(P<0。05);150 例血脂异常患者中,其中 10 例为原发性血脂异常(6。67%)、140 例为继发性血脂异常(93。33%);TG、TC、HDL-C与ApoB无明显关联性,差异无统计学意义(P>0。05),LDL-C与ApoB呈正相关,差异具有统计学意义(P<0。05)。结论 血脂异常患者中常见为继发性血脂异常,ApoB代谢异常与低密度脂蛋白异常有关联,在对怀疑为高脂血症患者中,开展ApoB测定后可预判疾病发生和发展,对临床后续治疗方案拟定及预后评估提供参考依据。
Study on the Correlation between Apolipoprotein B Metabolic Level and Blood Lipid Indicators in Patients with Dyslipidemia
Objective To explore the correlation between the metabolic level of apolipoprotein B(ApoB)and blood lipid indicators in patients with dyslipidemia.Methods 150 patients with dyslipidemia admitted to the Fourth Clinical College of Xinxiang Medical University,Xinxiang Central Hospital from October 2021 to October 2022 were selected as the research group.According to the type of dyslipidemia,they were divided into hypercholesterolemia,hypertriglyceridemia,mixed hyperlipidemia,and low high-density lipoprotein cholesterol.At the same time,150 healthy people who underwent physical examination were selected as the control group.Both groups underwent total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and apolipoprotein B(ApoB)tests,and the blood lipid-related indicators of the research group and the control group were analyzed.The test analysis results and the correlation between ApoB and other indicators were discussed.Results The LDL-C,TG,TC,and ApoB indicators of the research group were higher than those of the control group,while the HDL-C indicator was lower than that of the control group,with statistically significant differences(P<0.05).Among the 150 patients with dyslipidemia,10 cases were primary dyslipidemia(6.67%)and 140 cases were secondary dyslipidemia(93.33%).There was no obvious correlation between TG,TC,HDL-C and ApoB,and the difference was not statistically significant(P>0.05).LDL-C was positively correlated with ApoB,and the difference was statistically significant(P<0.05).Conclusion Secondary dyslipidemia is common in patients with dyslipidemia,and ApoB metabolic abnormalities are related to low-density lipoprotein abnormalities.In patients suspected of hyperlipidemia,the detection of ApoB can predict the occurrence and development of the disease,and provide a reference for the formulation of subsequent clinical treatment plans and prognosis evaluation.

dyslipidemiablood biochemistryapolipoprotein Bmetabolism

王娜、王雯茜、周明

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新乡市中心医院新乡医学院第四临床学院 检验科,河南 新乡 453000

血脂异常 血生化 载脂蛋白B 代谢

2024

临床研究
西安交通大学

临床研究

影响因子:0.234
ISSN:2096-1278
年,卷(期):2024.32(8)