Study on the Diagnosis of Kawasaki Disease with Coronary Artery Lesions using Dynamic Electrocardiogram and sST2,PAI-1
Objective To explore the significance of dynamic electrocardiogram and soluble suppression of tumorigenicity 2(sST2),plasminogen activator inhibitor-1(PAI-1)in the diagnosis of Kawasaki disease with coronary artery lesions.Methods A total of 102 children with Kawasaki disease treated in The First Affiliated Hospital of Zhengzhou University from January 2018 to January 2024 were selected as research subjects.According to whether the children had coronary artery lesions,they were divided into two groups:the lesion group(40 cases)and the non-lesion group(62 cases).The clinical case data[gender,age,body mass index(BMI),duration of fever,white blood cell count,25-hydroxyvitamin D3(25-(OH)D3),hemoglobin,platelet count,creatine kinase isoenzyme(CK-MB),N-terminal pro-brain natriuretic peptide(NT-proBNP),C-reactive protein(CRP),sST2,PAI-1]and the abnormal rate of dynamic electrocardiogram were compared between the two groups.The influencing factors of Kawasaki disease with coronary artery lesions were analyzed by multiple factors,and the ROC curve was drawn to evaluate the diagnostic value of different indicators for Kawasaki disease with coronary artery lesions.Results The duration of fever,platelet count,CRP,CK-MB,NT-proBNP,sST2,PAI-1 levels in the lesion group were higher than those in the non-lesion group,and the level of 25-(OH)D3 was lower than that in the non-lesion group,the differences were statistically significant(P＜0.05).The abnormal rate of dynamic electrocardiogram in the lesion group was 60.00%,and that in the non-lesion group was 16.13%.The lesion group was higher than the non-lesion group,and the difference was statistically significant(P＜0.05).The results of binary Logistic analysis showed that the duration of fever,25-(OH)D3,platelet count,CRP,CK-MB,NT-proBNP,sST2,PAI-1,and abnormal dynamic electrocardiogram were the influencing factors of Kawasaki disease with coronary artery lesions(P＜0.05).The ROC curve of diagnosing Kawasaki disease with coronary artery lesions was drawn with sST2,PAI-1,abnormal dynamic electrocardiogram and the combined application of the three indicators as variables.The AUC of sST2 was 0.789,the AUC of PAI-1 was 0.729,the AUC of abnormal dynamic electrocardiogram was 0.719,and the AUC of combined detection was 0.978.Conclusion The levels of dynamic electrocardiogram and sST2,PAI-1 have a high diagnostic value for whether Kawasaki disease is accompanied by CAL.
万方数据
维普
