Clinical Study on Panretinal Photocoagulation Combined with Medication for Diabetic Retinopathy
Objective To investigate the therapeutic effect of panretinal photocoa gulation(PRP)combined with anti-vascular endothelial growth factor(VEGF)drugs on diabetic retinopathy(DR).Methods A total of 89 DR patients treated at Nanyang Second People's Hospital from January 2023 to December 2023 were selected as research subjects.They were randomly divided into a control group(44 cases,78 eyes)and a study group(45 cases,81 eyes)using a random number table method.The control group received PRP treatment,while the study group received anti-VEGF drugs combined with PRP treatment.The efficacy,best-corrected visual acuity(BCVA),central macular thickness(CMT),degree of retinal microvascular lesions,and hemorheological indicators were compared between the two groups.Results The effective rate of treatment in the study group was higher than that in the control group,with a statistically significant difference(P＜0.05).There was no statistically significant difference in BCVA and CMT levels between the two groups before and 2 weeks after surgery(P＞0.05).At 4,6,and 12 weeks after surgery,the BCVA level in the study group was higher than that in the control group,and the CMT level was lower than that in the control group,with statistically significant differences(P＜0.05).The CMT level in the study group was lower than before surgery at 2 weeks after surgery.The BCVA levels in both groups at 4,6,and 12 weeks after surgery were higher than before surgery and 2 weeks after surgery,and the CMT levels were lower than before surgery and 2 weeks after surgery,with statistically significant differences(P＜0.05).There was no statistically significant difference in the degree of retinal microvascular lesions between the two groups before surgery(P＞0.05).Compared with the same group before surgery,the number of microaneurysms,exudation foci,and hemorrhage areas decreased at 12 weeks after surgery,and the study group was lower than the control group,with statistically significant differences(P＜0.05).There was no statistically significant difference in hemorheological indicators between the two groups before surgery(P＞0.05).At 12 weeks after surgery,the whole blood viscosity,plasma viscosity,and erythrocyte sedimentation rate in both groups decreased,and the study group was lower than the control group,with statistically significant differences(P＜0.05).Conclusion The combination of anti-VEGF drugs and PRP has a significant therapeutic effect on DR,can improve postoperative vision and central macular thickness,alleviate the degree of retinal microvascular lesions,and regulate hemorheological conditions.
万方数据
维普
