Clinical Efficacy and Safety Observation of Methimazole Combined with Glucocorticoids in the Treatment of Hyperthyroidism Complications
Objective To analyze the actual efficacy and safety of methimazole combined with glucocorticoids in the treatment of hyperthyroidism complications.Methods Seventy-six patients with hyperthyroidism complications admitted to Jili People's Hospital,Mengjin District,Luoyang,from January 2022 to August 2023 were selected as the study subjects.They were randomly divided into two groups using a random odd-even number method(odd numbers in the control group and even numbers in the study group),with 38 cases in each group.The control group received methimazole treatment alone,while the study group received methimazole combined with glucocorticoid treatment(prednisone acetate tablets).The treatment efficacy,Burch-Wartofsky point scale(BWPS)before and after treatment,thyroid indicators[free triiodothyronine(FT3),Free thyroxineIndex(FT4)],and adverse reactions during treatment were compared between the two groups.Results The treatment efficacy in the study group(97.37%)was higher than that in the control group(81.58%),with statistically significant differences(P＜0.05).There was no statistically significant difference in BWPS scores between the two groups before treatment(P＞0.05).After treatment,the BWPS scores in both groups were lower than before treatment,and the scores in the study group were lower than those in the control group,with statistically significant differences(P＜0.05).There was no statistically significant difference in FT3 and FT4 levels between the two groups before treatment(P＞0.05).After treatment,the FT3 and FT4 levels in both groups were lower than before treatment,and the levels in the study group were lower than those in the control group,with statistically significant differences(P＜0.05).The incidence of adverse reactions during treatment in the control group(7.89%)was not significantly different from that in the study group(10.53%)(P＞0.05).Conclusion The combination of methimazole and glucocorticoids in the treatment of hyperthyroidism complications can achieve therapeutic effects,and the safety of the medication is guaranteed,making it worthy of application.
万方数据
维普
