Analysis of the Efficacy and Mechanism of Budesonide Combined with Terbutaline Nebulization in the Treatment of Pediatric Bronchitis
Objective To investigate the efficacy and mechanism of budesonide combined with terbutaline nebulization in the treatment of pediatric bronchitis.Methods According to the random number table method,100 children with bronchitis treated at Taiqian County People's Hospital from January 2021 to October 2022 were divided into a control group and a study group,with 50 cases in each group.All children received conventional treatment after admission.The control group was treated with terbutaline,while the study group was treated with budesonide in addition to terbutaline for one week.The efficacy,symptom improvement time,inflammatory response,lung function,immune function changes before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The treatment efficacy in the study group(94.00%)was higher than that in the control group(80.00%),with statistically significant differences(P＜0.05).The symptom improvement time in the study group was shorter than that in the control group,with statistically significant differences(P＜0.05).After treatment,the levels of interleukin-8(IL-8),C-reactive protein(CRP),procalcitonin(PCT),and tumor necrosis factor-α(TNF-α)in the study group were lower than those in the control group,with statistically significant differences(P＜0.05).After treatment,the forced expiratory volume in one second(FEV1)/forced vital capacity(FVC)and peak expiratory flow(PEF)in the study group were higher than those in the control group,with statistically significant differences(P＜0.05).After treatment,the levels of CD3+,CD4+,and CD4+/CD8+in the study group were higher than those in the control group,while the level of CD8+was lower than that in the control group,with statistically significant differences(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of budesonide and terbutaline nebulization in the treatment of pediatric bronchitis is effective,can alleviate symptoms,inhibit inflammatory response,improve lung function and immune function,and has good clinical safety,making it worthy of clinical application.
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