The Effect of Esketamine Combined Anesthesia on Hemodynamics in Patients Undergoing Thoracoscopic Lobectomy
Objective To study the effect of esketamine combined anesthesia on patients undergoing thoracoscopic lobectomy. Methods Sixty-two lung cancer patients who underwent thoracoscopic lobectomy at Hebi People's Hospital from May 2022 to December 2023 were randomly divided into a control group (intravenous-inhalation combined anesthesia) and a study group (esketamine+intravenous-inhalation combined anesthesia). Hemodynamic indicators were compared between the two groups at 10 minutes before anesthesia induction (T0),10 minutes after anesthesia induction (T1),10 minutes after skin incision (T2),and at the end of surgery (T3). Stress indicators and inflammatory factor levels were compared 1 hour before and 1 hour after surgery,as well as pain scores at 1 hour,3 hours,and 6 hours after surgery,and the incidence of complications. Results At T0,the mean arterial pressure and heart rate of the two groups were basically consistent,with no statistically significant difference (P>0.05). At T1～T3,the mean arterial pressure and heart rate of the study group were higher than those of the control group,with statistically significant differences (P<0.05). During T0～T3,the mean arterial pressure and heart rate of both groups were within the normal range,and there was no statistically significant difference in the abnormal rate between the two groups (P>0.05). One hour before surgery,the levels of norepinephrine (NE) and cortisol (COR) in the two groups were basically consistent,with no statistically significant difference (P>0.05). One hour after surgery,the levels of NE and COR in the study group were lower than those in the control group,with statistically significant differences (P<0.05). The abnormal rates of NE and COR in the study group were lower than those in the control group 1 hour after surgery,with statistically significant differences (P<0.05). At 1 hour,3 hours,and 6 hours after surgery,the pain scores of the study group were lower than those of the control group,with statistically significant differences (P<0.05). One hour before surgery,the levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in the two groups were basically consistent,with no statistically significant difference (P>0.05). One hour after surgery,the levels of CRP and IL-6 in the study group were lower than those in the control group,with statistically significant differences (P<0.05). The abnormal rates of CRP and IL-6 in the study group were lower than those in the control group 1 hour after surgery,with statistically significant differences (P<0.05). The incidence of complications in the study group was lower than that in the control group,with statistically significant differences (P<0.05). Conclusion Esketamine combined anesthesia for patients undergoing thoracoscopic lobectomy helps maintain hemodynamic stability,reduces stress response,alleviates postoperative pain,inhibits inflammatory response,and prevents various complications,showing high application value.
万方数据
维普
