Study on the Drug Resistance and Risk Factors of Carbapenem-Resistant Enterobacteriaceae Infections in Elderly Inpatients
Objective To analyze the drug resistance and risk factors of carbapenem-resistant Enterobacteriaceae infections in elderly inpatients,providing a reference for subsequent treatment.Methods Ninety-two elderly patients admitted to Anyang People's Hospital from August 2020 to August 2023 were divided into a non-infected group(46 cases)and an infected group(46 cases)based on whether they were infected with carbapenem-resistant Enterobacteriaceae.The drug resistance of the bacteria in the infected group was analyzed,and the general data of the elderly patients were compared.The variables with differences were included in a binary logistic regression model to analyze the risk factors for carbapenem-resistant Enterobacteriaceae infections in elderly patients.Results carbapenem-resistant Enterobacteriaceae showed high resistance to most β-lactam antibiotics,with absolute resistance to ampicillin/sulbactam,aztreonam,and cefazolin.However,it showed higher sensitivity to amikacin and trimethoprim/sulfamethoxazole.There were no statistically significant differences in gender and age between the two groups(P＞0.05).The differences in underlying diseases,invasive procedures,history of recurrent infections,history of antibiotic use,and the number of hospitalizations in the year before admission were statistically significant(P＜0.05),and these were all risk factors for carbapenem-resistant Enterobacteriaceae infections.Conclusion carbapenem-resistant Enterobacteriaceae infections in elderly inpatients show high resistance to β-lactam antibiotics.Factors influencing carbapenem-resistant Enterobacteriaceae infections in elderly inpatients include underlying diseases,invasive procedures,history of recurrent infections,history of antibiotic use,and increased number of hospitalizations in the year before admission.Clinical interventions should focus on these risk factors to avoid unnecessary invasive procedures and reduce the incidence of infections.
万方数据
维普
