Objective To explore the efficacy of combining Shugan Jieyu Capsules with escitalopram in the treatment of post-stroke depression and its effects on 5-hydroxytryptamine(5-HT)and neurotransmitter power.Methods From June 2020 to June 2023,patients with post-stroke depression admitted to the People's Hospital of Jiyuan were classified according to traditional Chinese medicine syndrome differentiation.A total of 96 patients with liver depression and spleen deficiency were selected as research subjects and randomly divided into two groups,with 48 cases in each group.All 96 patients received routine treatment.The control group was treated with escitalopram,while the observation group was treated with Shugan Jieyu Capsules combined with escitalopram.The Hamilton Depression Scale(HAMD)scores,Hamilton Anxiety Scale(HAMA)scores,NIH Stroke Scale(NIHSS)scores,5-HT levels,neurotransmitter power,efficacy,and adverse reactions were compared between the two groups before and after treatment.Results After treatment,the HAMD,HAMA,and NIHSS scores in the observation group were significantly lower than those in the control group,with statistically significant differences(P＜0.05).After treatment,the 5-HT concentrations in both groups increased,and the 5-HT concentration in the observation group was significantly higher than that in the control group,with the differences being statistically significant(P＜0.05).After treatment,the neurotransmitter power of glutamate(Glu),γ-aminobutyric acid(GABA),dopamine(DA),and acetylcholine(Ach)in the observation group was significantly higher than that in the control group,with statistically significant differences(P＜0.05).The effective treatment rate in the observation group(95.83%)was higher than that in the control group(79.17%),with statistically significant differences(P＜0.05).There was no statistically significant difference in adverse reactions between the two groups after treatment(P＞0.05).Conclusion The combination of Shugan Jieyu Capsules and escitalopram in the treatment of post-stroke depression has good efficacy,can effectively increase plasma 5-HT levels and neurotransmitter power,reduce depression and anxiety,promote rapid recovery of neurological function,and has high medication safety.
关键词
舒肝解郁胶囊/艾司西酞普兰/脑梗死后抑郁症/5-羟色胺/神经递质功率
Key words
Shugan Jieyu Capsules/escitalopram/post-stroke depression/serotonin/neurotransmitter power
维普
万方数据