Clinical Efficacy of Modified Sini Powder Combined with Guizhi Gancao Longgu Muli Decoction in the Treatment of Polycystic Ovary Syndrome with Circadian Rhythm Disorder
Objective To explore the clinical efficacy of modified Sini Powder combined with Guizhi Gancao Longgu Muli Decoction in the treatment of polycystic ovary syndrome(PCOS)with circadian rhythm disorder.Methods A total of 100 patients with PCOS and circadian rhythm disorder treated at our hospital from January 2023 to March 2024 were selected and randomly divided into a study group(n=50)and a control group(n=50)using a random number table.The control group received conventional Western medicine treatment,while the study group received modified Sini Powder combined with Guizhi Gancao Longgu Muli Decoction in addition to the conventional treatment.The clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,hormone levels,ultrasound examination results(number of follicles,ovarian volume),and sleep quality were compared between the two groups.Results The treatment efficacy in the study group(98.00%)was higher than that in the control group(84.00%),with statistically significant differences(P＜0.05).After treatment,the TCM syndrome scores in both groups decreased,and the scores in the study group were lower than those in the control group,with statistically significant differences(P＜0.05).After treatment,the serum levels of luteinizing hormone(LH),testosterone(T),and estradiol(E2)decreased,and the levels of follicle-stimulating hormone(FSH)increased in both groups.The LH,T,and E2 levels in the study group were lower than those in the control group,while the FSH level was higher,with statistically significant differences(P＜0.05).After treatment,the number of follicles decreased,and the ovarian volume reduced in both groups.The number of follicles and ovarian volume in the study group were lower than those in the control group,with statistically significant differences(P＜0.05).After treatment,the Pittsburgh Sleep Quality Index(PSQI)scores in both groups decreased,and the scores in the study group were lower than those in the control group,with statistically significant differences(P＜0.05).Conclusion The combination of modified Sini Powder and Guizhi Gancao Longgu Muli Decoction with Western medicine treatment in patients with PCOS and circadian rhythm disorder can improve clinical efficacy,alleviate TCM syndromes,regulate hormone levels,improve ovarian abnormalities,and enhance sleep quality.
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