Evaluation Value of AFP,CEA,and CA125 Detection in Residual Cancer after Interventional Therapy for Primary Liver Cancer
Objective To analyze the evaluation value of alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),and carbohydrate antigen 125(CA125)levels in the detection of residual cancer after interventional therapy for primary liver cancer,both individually and in combination.Methods Seventy patients with residual cancer after interventional therapy for primary liver cancer treated at Nanle Zhongxing Hospital from March 2019 to March 2021 were selected as the experimental group.Another 70 patients without residual cancer after surgery during the same period were selected as the control group.Both groups were tested for AFP,CEA,and CA125 levels.Kendall's tau-b(K)correlation analysis was used to analyze the correlation between AFP,CEA,and CA125 levels and the occurrence of residual cancer after interventional therapy for primary liver cancer.Logistic binary regression analysis was used to analyze the influencing factors of residual cancer after interventional therapy for primary liver cancer.ROC curves were drawn to analyze the diagnostic value of AFP,CEA,and CA125 levels individually and in combination for residual cancer after interventional therapy for primary liver cancer.Results There were no statistically significant differences in gender,age,and Child-Pugh classification between the two groups(P＞0.05).The serum levels of AFP,CEA,and CA125 in the experimental group were higher than those in the control group,with statistically significant differences(P＜0.05).Kendall's tau-b(K)correlation analysis showed a positive correlation between the occurrence of residual cancer after interventional therapy for primary liver cancer and AFP,CEA,and CA125 levels(r＞0,P＜0.05).Logistic regression analysis showed that AFP,CEA,and CA125 levels were risk factors for residual cancer after interventional therapy for primary liver cancer(OR＞1,P＜0.05).ROC curve analysis showed that the AUCs for the diagnosis of residual cancer after interventional therapy for primary liver cancer using AFP,CEA,and CA125 individually and in combination were 0.924(95%CI:0.884～0.965),0.730(95%CI:0.642～0.817),0.835(95%CI:0.769～0.901),and 0.968(95%CI:0.941～0.994),respectively.Conclusion AFP,CEA,and CA125 detection has certain evaluation value for residual cancer after interventional therapy for primary liver cancer.Combined detection can improve predictive value and is worthy of application.
万方数据
维普
