Changes in Serum Irisin,High Mobility Group Box 1,and Neuregulin 4 Levels in Patients with Early Diabetic Kidney Disease and Their Clinical Significance
Objective To investigate the changes in serum irisin,high mobility group box 1(HMGB1),and neuregulin 4(NRG4)levels in patients with early diabetic kidney disease(DKD)and their clinical significance.Methods A total of 80 patients with early DKD treated at the first affiliated hospital of zhengzhou university from March 2022 to March 2024 were selected as the early DKD group,and 50 healthy individuals undergoing physical examination during the same period were selected as the healthy control group.Demographic characteristics and clinical data of the two groups were collected,and serum irisin,HMGB1,and NRG4 levels were measured.Univariate and multivariate logistic regression analyses were performed to identify risk factors for early DKD.Results There were no statistically significant differences in age,gender,history of alcohol consumption,history of coronary heart disease,history of smoking,history of hypertension,diastolic blood pressure,systolic blood pressure,high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)levels between the two groups(P＞0.05).The early DKD group had lower serum irisin and NRG4 levels and higher HMGB1 levels,with statistically significant differences(P＜0.05).Multivariate binary logistic regression analysis showed that serum irisin(OR=0.568;95%CI:0.389～0.829)and NRG4(OR=0.456;95%CI:0.246～0.845)were protective factors for early DKD,with statistically significant differences(P＜0.05),while HMGB1(OR=2.976;95%CI:2.664～3.325)was an independent risk factor,with a statistically significant difference(P＜0.05).Conclusion Patients with early DKD have lower serum irisin and NRG4 levels and higher HMGB1 levels.Serum irisin,HMGB1,and NRG4 levels can be used to assess the occurrence of early DKD.
early diabetic kidney diseaseserum irisinhigh mobility group box 1neuregulin 4clinical significance
万方数据
维普
