首页|左卡尼汀联合高通量血液透析对尿毒症患者血常规、营养指标及肾功能的影响观察

左卡尼汀联合高通量血液透析对尿毒症患者血常规、营养指标及肾功能的影响观察

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目的 观察左卡尼汀与高通量血液透析(HFD)联合方案治疗尿毒症患者的效果。方法 选取 2021 年 12 月至2023 年 12 月南京市栖霞区医院收治的 92 例尿毒症患者,收集其临床资料展开回顾性分析,以是否接受左卡尼汀治疗作为分组依据,参照组仅实施HFD(n=46),研究组在参照组基础上联用左卡尼汀治疗(n=46),对两组血常规、营养指标、肾功指标变化情况展开比较。结果 治疗后两组血红蛋白(Hb)、红细胞压积(Hct)、白蛋白(Alb)、铁蛋白(Fer)指标均高于治疗前,且研究组高于参照组,差异有统计学意义(P<0。05);治疗后两组甲状旁腺激素(PTH)、尿酸(UA)、肌酐(Cr)、尿素(BUN)指标均低于治疗前,且研究组低于参照组,差异有统计学意义(P<0。05)。结论 尿毒症患者实施HFD联合左卡尼汀治疗方案,可以改善机体代谢及微炎症状态,延缓残余肾功能减退,改善贫血、营养问题,提高患者生存质量,具有良好应用价值。
Observation of the Effects of L-Carnitine Combined with High-Flux Hemodialysis on Blood Routine,Nutritional Indicators,and Renal Function in Uremic Patients
Objective To observe the effect of L-Carnitine combined with high-flux hemodialysis(HFD)in the treatment of uremic patients.Methods From December 2021 to December 2023,92 uremic patients admitted to Qixia District Hospital were selected for retrospective analysis.They were divided into control group(only HFD,n=46)and study group(HFD combined with L-Carnitine,n=46)based on whether they received L-Carnitine treatment.Changes in blood routine,nutritional indicators,and renal function were compared between the two groups.Results After treatment,hemoglobin(Hb),hematocrit(Hct),albumin(Alb),and ferritin(Fer)levels in both groups were higher than before treatment,with the study group being significantly higher than the control group(P<0.05).Parathyroid hormone(PTH),uric acid(UA),creatinine(Cr),and blood urea nitrogen(BUN)levels in both groups were lower than before treatment,with the study group being significantly lower than the control group(P<0.05).Conclusion The combination of HFD and L-Carnitine in the treatment of uremic patients can improve metabolic and micro-inflammatory states,delay the decline of residual renal function,improve anemia and nutritional issues,and enhance patients'quality of life,demonstrating good application value.

L-Carnitinehigh-flux hemodialysisuremiablood routinerenal function

孔若曦、孙静雯、闫文娟

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南京市栖霞区医院 肾内科,江苏 南京 210046

南京市栖霞区医院 血透室,江苏 南京 210046

南京医科大学附属南京医院(南京市第一医院)肾内科,江苏 南京 210006

左卡尼汀 高通量血液透析 尿毒症 血常规 肾功能

南京医科大学科技发展基金资助项目

NMUB20210215

2024

临床研究
西安交通大学

临床研究

影响因子:0.234
ISSN:2096-1278
年,卷(期):2024.32(10)