The Effect of Ambroxol Hydrochloride Combined with Cefixime on Pediatric Asthmatic Bronchitis
Objective To analyze the efficacy and safety of ambroxol hydrochloride combined with cefixime in the treatment of pediatric asthmatic bronchitis,and to explore its effects on airway remodeling,inflammatory response,and respiratory function in children.Methods According to the random number table method,90 children with asthmatic bronchitis who were treated at Pingqiao District Maternal and Child Health Hospital from January 2020 to January 2022 were selected.The control group(45 children)received cefixime treatment,while the observation group(45 children)received ambroxol hydrochloride treatment in addition to cefixime.Both groups were treated for 7 days.The efficacy and incidence of adverse reactions were compared between the two groups.Inflammatory response indicators[C-reactive protein(CRP),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]and respiratory function indicators[forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),maximal mid-expiratory flow(MMEF)]were compared between the two groups.The levels of airway remodeling indicators[matrix metalloproteinase-9(MMP-9),tissue inhibitor of metalloproteinases-1(TIMP-1)]were also compared between the two groups.Results After 7 days of treatment,the effective rate of treatment in the observation group(95.56%)was higher than that in the control group(68.89%),with a statistically significant difference(P＜0.05).After 7 days of treatment,the levels of CRP,IL-8,IL-6,and TNF-α in both groups were lower than before treatment,and the levels in the observation group were lower than those in the control group,with a statistically significant difference(P＜0.05).After 7 days of treatment,the levels of FVC,FEV1,and MMEF in both groups were higher than before treatment,and the levels in the observation group were higher than those in the control group,with a statistically significant difference(P＜0.05).After 7 days of treatment,the levels of MMP-9 and TIMP-1 in both groups were lower than before treatment,and the MMP-9/TIMP-1 ratio was higher than before treatment.The levels of MMP-9 and TIMP-1 in the observation group were lower than those in the control group,and the MMP-9/TIMP-1 ratio was higher than that in the control group,with a statistically significant difference(P＜0.05).During the treatment period,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The treatment of pediatric asthmatic bronchitis with ambroxol hydrochloride combined with cefixime is effective,can inhibit the high expression of inflammatory factors,improve respiratory function and airway remodeling,and has good medication safety.
pediatric asthmatic bronchitisambroxol hydrochloridecefiximeairway remodelinginflammatory responserespiratory function
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