Clinical Effect of Modified Tongfu Xingshen Decoction Combined with Xingnaojing Injection in the Treatment of Acute Cerebral Hemorrhage
Objective To investigate the clinical effect of Modified Tongfu Xingshen Decoction combined with Xingnaojing Injection in the treatment of acute cerebral hemorrhage.Methods A total of 120 patients with acute cerebral hemorrhage treated at Jinshui District General Hospital from February 2022 to February 2023 were selected as study subjects.The subjects were divided into a single-drug group(60 cases)and a combined group(60 cases)using the random number table method.The combined group was treated with modified Tongfu Xingshen Decoction combined with Xingnaojing Injection,while the single-drug group was treated with Xingnaojing Injection alone.The clinical efficacy,vascular endothelial function indicators,inflammatory cytokines,hemorheology,neurological deficit,and incidence of adverse reactions were compared between the single-drug group and the combination group.Results After treatment,the effective rate of the combined group was higher than that of the single-drug group,with a statistically significant difference(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the combined group and the single-drug group(P＞0.05).Before treatment,there were no statistically significant differences in hemorheology indicators,vascular endothelial function,neurological deficit scores,and inflammatory cytokine levels between the two groups(P＞0.05).After treatment,the low-shear reduced viscosity,high-shear reduced viscosity,endothelin-1(ET-1),neurological deficit degree,and inflammatory cytokine levels of both groups were lower than before treatment,while the nitric oxide(NO)level was higher than before treatment.In addition,The low-shear reduced viscosity,high-shear reduced viscosity,ET-1,neurological deficit degree,and inflammatory cytokine levels of the combined group were lower than those of the single-drug group,while the NO level was higher than that of the single-drug group,with statistically significant differences(P＜0.05).Conclusion Modified Tongfu Xingshen Decoction combined with Xingnaojing Injection can improve clinical treatment efficacy,improve hemorheology indicators and vascular endothelial function,reduce the degree of neurological deficit,lower inflammatory cytokine levels,and promote the recovery of patients with acute cerebral hemorrhage.
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