Significance of Detecting PCT and NT-proBNP in Patients with Acute Myocardial Infarction Complicated with Heart Failure
Objective To investigate the changes and significance of procalcitonin(PCT)and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels in patients with acute myocardial infarction(AMI)complicated with heart failure(HF).Methods A total of 68 patients with AMI complicated with HF admitted to Zhengzhou 460 Hospital from May 2022 to May 2023 were selected as the experimental group,and 60 AMI patients treated in the same period were selected as the control group.Baseline data of the two groups[systolic blood pressure(SBP),diastolic blood pressure(DBP),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C)/low-density lipoprotein cholesterol(LDL-C),white blood cell count(WBC)]were collected.Serum PCT,NT-proBNP,and cardiac function indicators were measured.The baseline data of the two groups were compared,and the serological indicators of patients with different cardiac function grades in the experimental group were compared.The correlation between serum PCT,NT-proBNP levels,and cardiac function indicators was analyzed.Results The levels of serum PCT,NT-proBNP,left ventricular end-diastolic diameter(LVEDD),and left atrial end-diastolic diameter(LAED)in the experimental group were higher than those in the control group,while the level of left ventricular ejection fraction(LVEF)was lower than that in the control group,with statistically significant differences(P＜0.05).There were no statistically significant differences in SBP,DBP,heart rate,TC,TG,HDL-C,LDL-C,and WBC levels between the two groups(P＞0.05).With the increase in cardiac function grade,the levels of serum PCT and NT-proBNP gradually increased,with statistically significant differences(P＜0.05).Serum PCT and NT-proBNP levels were positively correlated with LVEDD and LAED(r=0.432,0.557,0.597,0.783,P＜0.05),and negatively correlated with LVEF levels(r=-0.400,-0.422,P＜0.05).Conclusion The levels of serum PCT and NT-proBNP in patients with AMI complicated with HF are abnormally elevated,and the differences in these indicators are significant among different cardiac function grades.Serum PCT and NT-proBNP levels are positively correlated with LVEDD and LAED,and negatively correlated with LVEF.Detecting PCT and NT-proBNP levels can be used to assess the cardiac function of patients with AMI complicated with HF.
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