三联检测在儿童急性髓系白血病伴随感染的诊断价值
Diagnostic Value of Triple Testing in Pediatric Acute Myeloid Leukemia with Accompanying Infection
崔昭婷 1苏丽 2杨杰 2段广才3
作者信息
- 1. 郑州大学公共卫生学院 流行病与卫生统计学,河南 郑州 450000;郑州市第三人民医院 中心实验室,河南 郑州 450000
- 2. 郑州市第三人民医院 检验科,河南 郑州 450000
- 3. 郑州大学公共卫生学院 流行病与卫生统计学,河南 郑州 450000
- 折叠
摘要
目的 探讨白介素-6(IL-6)、降钙素原(PCT)、C反应蛋白(CRP)三联检测在儿童急性髓系白血病伴随感染中的诊断价值.方法 选取 2023 年 1 月至 2024 年 2 月郑州市第三人民医院 70 例白血病伴随感染患儿为感染组,同时以未发生感染的 70 例白血病患儿为未感染组,均开展IL-6、PCT、CRP联合检测,分析IL-6、PCT、CRP三联检测在儿童急性髓系白血病伴随感染的诊断效果.结果 感染组患儿IL-6、PCT、CRP水平均高于未感染组,差异均有统计学意义(P＜0.05);重度感染患儿IL-6、PCT、CRP水平均高于轻度感染患儿,差异均有统计学意义(P＜0.05);IL-6、PCT、CRP三联检测诊断儿童急性髓系白血病伴随感染的准确率为 95.00%,灵敏度为 97.14%,特异度为92.86%.结论 IL-6、PCT、CRP三联检测在儿童急性髓系白血病伴随感染的诊断效果确切,可为诊断儿童急性髓系白血病伴随感染提供依据.
Abstract
Objective To investigate the diagnostic value of triple testing for interleukin-6(IL-6),procalcitonin(PCT),and C-reactive protein(CRP)in pediatric acute myeloid leukemia with accompanying infection.Methods From January 2023 to February 2024,70 children with leukemia and accompanying infection were selected as the infection group in the Third People's Hospital of Zhengzhou,while 70 leukemia children without infection were selected as the non-infection group.IL-6,PCT,and CRP joint detection was carried out in both groups to analyze the diagnostic effect of the triple testing in pediatric AML with accompanying infection.Results The levels of IL-6,PCT,and CRP in the infection group were all significantly higher than those in the non-infection group(P＜0.05).The levels of IL-6,PCT,and CRP in children with severe infection were higher than those in children with mild infection(P＜0.05).The accuracy,sensitivity,and specificity of the triple testing in diagnosing pediatric AML with accompanying infection were 95.00%,97.14%,and 92.86%,respectively.Conclusion The triple testing for IL-6,PCT,and CRP has a definite diagnostic effect in pediatric AML with accompanying infection and can provide a basis for diagnosis.
关键词
白介素-6/降钙素原/C反应蛋白/白血病/儿童/感染Key words
interleukin-6/procalcitonin/C-reactive protein/leukemia/children/infection引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据