首页|孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床价值分析

孟鲁司特钠治疗小儿咳嗽变异性哮喘的临床价值分析

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目的 探究咳嗽变异性哮喘患儿接受孟鲁司特钠治疗的效果.方法 选择天津市儿童医院 2021 年 8 月至2023 年 8 月收治的 80 例咳嗽变异性哮喘患儿作为本次研究对象,根据随机数字表法分为对照组(40 例,常规治疗)与研究组(40 例,在对照组基础上加以孟鲁司特钠治疗),对比两组治疗情况.结果 研究组治疗有效率(95.00%)高于对照组(80.00%),差异具有统计学意义(P<0.05).治疗后,两组肺功能指标水平均较治疗前升高,炎性因子水平均较治疗前降低,且研究组肺功能指标水平较对照组高,炎性因子水平较对照组低,差异均有统计学意义(P<0.05).研究组咳嗽、肺啰音、发热与憋喘消失时间均短于对照组,差异均有统计学意义(P<0.05).结论 在咳嗽变异性哮喘患儿中应用孟鲁司特钠治疗可有效提高治疗效果、改善肺功能、减轻炎症反应,缩短临床不适症状消失时间,值得临床应用.
Analysis of the Clinical Value of Montelukast Sodium in the Treatment of Cough Variant Asthma in Children
Objective To explore the effects of montelukast sodium treatment in children with cough variant asthma.Methods A total of 80 children diagnosed with cough variant asthma admitted to Tianjin Children's Hospital from August 2021 to August 2023 were selected for this study.They were randomly divided into a control group(40 cases,receiving conventional treatment)and a study group(40 cases,receiving montelukast sodium treatment in addition to conventional treatment).The treatment outcomes of the two groups were compared.Results The effective treatment rate in the study group(95.00%)was higher than that in the control group(80.00%),with a statistically significant difference(P<0.05).After treatment,the pulmonary function parameters of both groups increased compared to before treatment,and the levels of inflammatory factors decreased compared to before treatment.Furthermore,the pulmonary function parameters in the study group were significantly higher and the inflammatory factor levels were significantly lower than those in the control group(P<0.05).The time taken for cough,lung rales,fever,and wheezing to disappear in the study group was shorter than that in the control group,with all differences reaching statistical significance(P<0.05).Conclusion The application of montelukast sodium in children with cough variant asthma effectively improves treatment outcomes,enhances pulmonary function,reduces inflammatory responses,and shortens the duration of clinical symptoms,making it a valuable option for clinical practice.

cough variant asthmamontelukast sodiumpulmonary functionblood gas indicators

张晓梦

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天津市儿童医院(天津大学儿童医院)药剂科,天津 300134

咳嗽变异性哮喘 孟鲁司特钠 肺功能 血气指标

2024

临床研究
西安交通大学

临床研究

影响因子:0.234
ISSN:2096-1278
年,卷(期):2024.32(12)