The Efficacy of Bronchoalveolar Lavage in the Auxiliary Treatment of Severe Pneumonia Complicated with Respiratory Failure and Its Effects on Inflammatory Factors and Pulmonary Function
Objective To explore the application value of bronchoalveolar lavage(BAL)in the treatment of severe pneumonia complicated with respiratory failure.Methods A total of 80 patients with severe pneumonia complicated by respiratory failure admitted to the Third Affiliated Hospital of Xinxiang Medical University from January 2022 to May 2024 were included in the study.They were randomly divided into two groups:the control group receiving conventional treatment(n=40),and the experimental group receiving additional bronchoalveolar lavage as an auxiliary treatment based on conventional treatment(n=40).The efficacy,inflammatory factors,pulmonary function,and blood gas indicators of the two groups were observed.Results The effective treatment rate in the experimental group(90.00%)was higher than that in the control group(70.00%),with a statistically significant difference(P＜0.05).There was no significant difference in inflammatory factor levels between the two groups before treatment(P＞0.05).After treatment,levels of interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),and C-reactive protein(CRP)in the experimental group were significantly lower than those in the control group(P＜0.05).Before treatment,there were no significant differences in pulmonary function between the two groups(P＞0.05).After treatment,the forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),and FEV1/FVC ratio in the experimental group were all higher than those in the control group,with statistically significant differences(P＜0.05).Prior to treatment,there were no significant differences in arterial blood gas indicators between the two groups(P＞0.05).After treatment,the arterial blood oxygen saturation(SaO2)and arterial oxygen partial pressure(PaO2)in the experimental group were higher than those in the control group,while arterial carbon dioxide partial pressure(PaCO2)was lower than that in the control group,with statistically significant differences(P＜0.05).Conclusion The combination of bronchoalveolar lavage with conventional treatment for patients with severe pneumonia complicated by respiratory failure can effectively reduce levels of inflammatory factors and accelerate the recovery of pulmonary function,making it a valuable clinical approach.
severe pneumoniarespiratory failurebronchoalveolar lavagepulmonary function
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