Analysis of the Effects of Naloxone Combined with Immunoglobulin Therapy in Children with Viral Encephalitis
Objective To analyze the effects of naloxone combined with immunoglobulin therapy in the treatment of children with viral encephalitis.Methods A total of 78 children diagnosed with viral encephalitis who were admitted to Nanyang Central Hospital from December 2021 to December 2023 were included in the study.Patients were randomly divided into two groups using odd-even number drawing:39 patients were assigned to the control group and received conventional treatment,while the other 39 patients in the study group received naloxone combined with immunoglobulin therapy in addition to standard treatment.The treatment efficacy rates,duration until symptom resolution,and levels of inflammatory factors in cerebrospinal fluid[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α)]and serum neuron-specific enolase(NSE)before and after treatment were compared between the two groups.Results The treatment efficacy rate in the study group(94.87%)was significantly higher than that in the control group(74.36%),with a statistically significant difference(P＜0.05).The duration until resolution of fever,seizures,meningeal irritation signs,and consciousness disturbances in the study group were all significantly shorter than those in the control group(P＜0.05).There were no significant differences in the levels of inflammatory factors between the two groups before treatment(P＞0.05).After treatment,levels of CRP,TNF-α,and IL-6 were significantly lower than before treatment in both groups,and the study group had significantly lower levels than the control group(P＜0.05).Similarly,there were no significant differences in NSE levels between the two groups before treatment(P＞0.05),but after treatment,NSE levels were significantly lower than before treatment in both groups,with the study group showing significantly lower levels than the control group(P＜0.05).Conclusion The combined treatment of naloxone and immunoglobulin in children with viral encephalitis can accelerate the resolution of symptoms,promote the reduction of inflammation,and facilitate the recovery of neurological function,making it a valuable treatment option.
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