Comparison of the Clinical Application of Remifentanil Combined with Etomidate and Propofol in Orthopedic General Anesthesia Patients
Objective To compare the clinical effects of"remifentanil combined with etomidate and propofol"and"remifentanil combined with propofol"in patients undergoing orthopedic general anesthesia.Methods A total of 74 orthopedic patients who underwent general anesthesia at Luoyang Central Hospital from January 2022 to June 2024 were selected and divided into a study group(n=38)and a control group(n=36)based on the anesthesia regimen.The study group received anesthesia with"etomidate injection+propofol injection+remifentanil hydrochloride injection"and maintained anesthesia with etomidate.The control group received anesthesia with"propofol injection+remifentanil hydrochloride injection"and maintained anesthesia with propofol.The two groups were compared in terms of anesthesia induction time,recovery time,orientation recovery time,hemodynamic changes at different time points during anesthesia induction,the incidence of adverse reactions,and the quality of anesthesia.Results The anesthesia induction time,recovery time,and orientation recovery time in the study group were significantly shorter than those in the control group(P＜0.05).During anesthesia induction,there were no significant differences in baseline hemodynamic indicators between the two groups at time point T0(P＞0.05).At the point of loss of consciousness(T1),the diastolic pressure and heart rate(HR)in the study group were significantly higher than those in the control group(P＜0.05).At intubation(T2)and 5 minutes post-intubation(T4),the systolic pressure,diastolic pressure,mean arterial pressure(MAP),and HR were all significantly higher in the study group than in the control group(P＜0.05).One minute after intubation(T3),the study group's diastolic pressure,MAP,and HR were also significantly higher than those in the control group(P＜0.05).The incidence of adverse reactions during anesthesia was significantly lower in the study group(2.63%)compared to the control group(22.22%)(P＜0.05).Additionally,the quality of anesthesia was significantly better in the study group(97.37%)compared to the control group(75.00%)(P＜0.05).Conclusion The combination of remifentanil with etomidate and propofol for anesthesia in orthopedic patients is more beneficial than remifentanil combined with propofol alone in enhancing anesthesia quality and recovery quality,stabilizing hemodynamics during anesthesia,and reducing the incidence of anesthesia-related adverse reactions.
general anesthesiaremifentaniletomidatepropofolhemodynamics
国家科技期刊平台
NSTL
万方数据
