Analysis of the Efficacy and Safety of Xuanfei Tongluo Zhike Granules Combined with Budesonide Nebulization in the Treatment of Pediatric Asthma
Objective To explore the efficacy and safety of Xuanfei Tongluo Zhike Granules combined with budesonide nebulization in the treatment of pediatric asthma.Methods A total of 120 children with asthma admitted to the Pingqiao District Maternal and Child Health Hospital in Xinyang from February 2022 to February 2023 were selected and randomly divided into a control group and a combination group,with 60 cases in each group.The control group received budesonide nebulization,while the combination group received Xuanfei Tongluo Zhike Granules in addition to the treatment in the control group.The pulmonary function parameters[Forced Expiratory Volume in 1 second(FEV1),Peak Expiratory Flow(PEF),Forced Vital Capacity(FVC)],inflammatory factors[Tumor Necrosis Factor-alpha(TNF-α),Interleukin-4(IL-4),Intercellular Adhesion Molecule-1(ICAM-1),Immunoglobulin E(IgE)],recovery times of symptoms and signs,and the effective rate of asthma treatment were compared between the two groups.Results Before treatment,there were no statistically significant differences in pulmonary function parameters and inflammatory factor levels between the two groups(P＞0.05);after treatment,FEV1,FVC,and PEF levels increased in both groups,with the combination group showing higher FEV1,FVC,and PEF levels compared to the control group,and the differences were statistically significant(P＜0.05).Levels of TNF-α,IL-4,ICAM-1,and IgE decreased in both groups,with the combination group showing lower levels of TNF-α,IL-4,ICAM-1,and IgE than the control group,and the differences were statistically significant(P＜0.05).The time to improvement for cough,wheezing,shortness of breath,sputum production,and wheezing in the combination group was shorter than those in the control group,with significant differences(P＜0.05).The effective rate of treatment in the combination group was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion The combination of Xuanfei Tongluo Zhike Granules and budesonide nebulization effectively improves pulmonary function in children with asthma,alleviates inflammation,and demonstrates significant therapeutic effects with a satisfactory safety profile.
pediatric asthmaXuanfei Tongluo Zhike granulesBudesonidepulmonary functioninflammatory factorscough and sputum production
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