Analysis of the Application Effect of Combined Detection of Serum Ferritin and Alpha-Fetoprotein in Patients with Primary Liver Cancer
Objective To explore the application value of combined detection of serum ferritin and alpha-fetoprotein(AFP)in primary liver cancer(PHC).Methods A retrospective analysis was performed on clinical data from 76 patients with PHC(PHC group)and 30 patients with benign liver lesions(control group)who were treated at the Fifth People's Hospital of Anyang from March 2022 to February 2024.All cases were clinically diagnosed and underwent serum ferritin and AFP testing,with results compared between the two groups.Pathological examination was used as the gold standard to analyze the diagnostic efficacy of serum ferritin and AFP alone and in combination for PHC.In the PHC group,patients were staged according to the Barcelona Clinic Liver Cancer(BCLC)classification,and the levels of serum ferritin and AFP were compared across different stages.Results The levels of serum ferritin and AFP in the PHC group were significantly higher than those in the control group(P＜0.05).Serum ferritin and AFP alone identified 63 positive cases,while combined testing identified 71 positive cases.The sensitivity,specificity,and accuracy of combined detection for diagnosing PHC were 90.79%,93.33%,and 91.51%,respectively.Compared to individual tests,the combined testing showed higher sensitivity and accuracy,with significant differences(P＜0.05).For patients staged as C according to BCLC,the levels of serum ferritin and AFP were significantly higher than those in stages A and B;similarly,stage B patients had significantly higher levels than stage A patients,with statistically significant differences(P＜0.05).Conclusion There is a notable increase in serum ferritin and AFP levels in patients with PHC.The combined detection of serum ferritin and AFP demonstrates good diagnostic efficacy.Additionally,the later the stage of liver cancer,the more significant the changes in these biomarkers,which can provide auxiliary support for the assessment of the condition in PHC patients.
国家科技期刊平台
NSTL
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