Progress in research aimed at conversion and synthesis of medium-chain fatty acids using microbial carbon chain extension technology
Environmental pollution and resource shortages are major problems facing human society.To implement economically beneficial and environmentally friendly strategies,it is particularly important to develop clean and renewable chemicals and promote a sustainable energy supply in keeping with the concept of green ecology.Microbial carbon chain elongation(CE)is a novel technology that uses microorganisms to produce medium-chain fatty acids(MCFAs).In this paper,firstly,the principle and process of microbial CE technology are summarized,with emphasis on electron donor oxidation,reverseβoxidation,and fatty acid synthesis.Key factors impacting microbial CE,including electron donor and acceptor,pH,temperature,inoculum source,reactor design,and operating parameters(SRT/HRT)were further analyzed.Finally,the latest research progress in CE performance enhancement technologies is summarized in detail.Using microorganisms to catalyze CE,MCFAs with high added value can be produced.MCFA yield is improved by strengthening conductor material performance,specific drugs,and electrification,and incorporating the support of mathematical models,multivariate analysis,and other technologies.CE technology has shown great potential for optimization of resource utilization.Future studies should examine interactions between microbial community structure and environment and their function,focus on developing new separation and purification technologies and engineering strategies,and find sustainable low-cost raw materials as electron donors to reduce costs and improve MCFA yield and specificity.Microbial transformations to produce MCFAs can supplement carbon sources,slow global warming,and provide new guidance for resource utilization.