首页|Multi-omics landscape to decrypt the distinct flavonoid biosynthesis of Scutellaria baicalensis across multiple tissues

Multi-omics landscape to decrypt the distinct flavonoid biosynthesis of Scutellaria baicalensis across multiple tissues

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Scutellaria baicalensis Georgi,also known as huang-qin in traditional Chinese medicine,is a widely used herbal remedy due to its anticancer,antivirus,and hepatoprotective properties.The S.baicalensis genome was sequenced many years ago;by contrast,the proteome as the executer of most biological processes of S.baicalensis in the aerial parts,as well as the secondary structure of the roots(xylem,phloem,and periderm),is far less comprehensively characterized.Here we attempt to depict the molecular landscape of the non-model plant S.baicalensis through a multi-omics approach,with the goal of constructing a highly informative and valuable reference dataset.Furthermore,we provide an in-depth characterization dissection to explain the two distinct flavonoid biosynthesis pathways that exist in the aerial parts and root,at the protein and phosphorylated protein levels.Our study provides detailed spatial proteomic and phosphoproteomic information in the context of secondary structures,with implications for the molecular profiling of secondary metabolite biosynthesis in non-model medicinal plants.

Dandan Guo、Zhenyu Zhu、Zhe Wang、Fei Feng、Qi Cao、Zhewei Xia、Xinlei Jia、Diya Lv、Ting Han、Xiaofei Chen

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Pharmaceutical Analysis and Testing center,School of Pharmacy,Naval Medical University(Second Military Medical University),Shanghai,200433,China

Shanghai Key Laboratory for Pharmaceutical Metabolite Research,Shanghai,200433,China

Department of Physiology,College of Basic Medical Sciences,Naval Medical University(Second Military Medical University),Shanghai,200433,China

国家自然科学基金国家自然科学基金国家自然科学基金National Key Research and Development Program of Ministry of ChinaShanghai Sailing Program

8210432881973291821220662022YFC270460320YF1458900

2024

园艺研究(英文)

园艺研究(英文)

CSTPCD
ISSN:
年,卷(期):2024.11(1)
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