首页|Exploring N6-methyladenosine(m6A)modification in tree species:opportunities and challenges

Exploring N6-methyladenosine(m6A)modification in tree species:opportunities and challenges

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N6-methyladenosine(m6A)in eukaryotes is the most common and widespread internal modification in mRNA.The modification regulates mRNA stability,translation efficiency,and splicing,thereby fine-tuning gene regulation.In plants,m6A is dynamic and critical for various growth stages,embryonic development,morphogenesis,flowering,stress response,crop yield,and biomass.Although recent high-throughput sequencing approaches have enabled the rapid identification of m6A modification sites,the site-specific mechanism of this modification remains unclear in trees.In this review,we discuss the functional significance of m6A in trees under different stress conditions and discuss recent advancements in the quantification of m6A.Quantitative and functional insights into the dynamic aspect of m6 A modification could assist researchers in engineering tree crops for better productivity and resistance to various stress conditions.

Muthusamy Ramakrishnan、K.Shanmugha Rajan、Sileesh Mullasseri、Zishan Ahmad、Mingbing Zhou、Anket Sharma、Subbiah Ramasamy、Qiang Wei

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State Key Laboratory of Tree Genetics and Breeding,Co-Innovation Center for Sustainable Forestry in Southern China,Bamboo Research Institute,Key Laboratory of National Forestry and Grassland Administration on Subtropical Forest Biodiversity Conservation,School of Life Sciences,Nanjing Forestry University,Nanjing 210037,Jiangsu,China

Department of Chemical and Structural Biology,Weizmann Institute of Science,7610001 Rehovot,Israel

Department of Zoology,St.Albert's College(Autonomous),Kochi 682018,Kerala,India

State Key Laboratory of Subtropical Silviculture,Bamboo Industry Institute,Zhejiang A&F University,Lin'an,Hangzhou 311300,Zhejiang,China

Zhejiang Provincial Collaborative Innovation Center for Bamboo Resources and High-Efficiency Utilization,Zhejiang A&F University,Lin'an,Hangzhou 311300,Zhejiang,China

Cardiac Metabolic Disease Laboratory,Department of Biochemistry,School of Biological Sciences,Madurai Kamaraj University,Madurai 625021,Tamilnadu,India

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国家重点研发计划国家自然科学基金江苏省自然科学基金Jiangxi'Shuangqian'ProgramNatural Science Foundation for Distinguished Young Scholars of Nanjing Forestry UniversityProject for Groundbreaking Achievements of Nanjing Forestry University江苏高校优势学科建设工程项目Young Foreign Talent ProgramMetasequoia Faculty Research Startup Funding at the Bamboo Research Institute,Nanjing Forestry UniversityDean of Faculty FellowshipKoshland Prize,and a Sir Charles Clore Postdoctoral Fellowship from the Weizmann Institute

2021YFD2200503-0132071848BK20231289S2019DQKJ2030JC2019004202211QN2022014012L163100028

2024

10.1093/hr/uhad284

园艺研究(英文)

园艺研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.11(2)
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