首页|Advanced metabolic engineering strategies for increasing artemisinin yield in Artemisia annua L.

Advanced metabolic engineering strategies for increasing artemisinin yield in Artemisia annua L.

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Artemisinin,also known as'Qinghaosu',is a chemically sesquiterpene lactone containing an endoperoxide bridge.Due to the high activity to kill Plasmodium parasites,artemisinin and its derivatives have continuously served as the foundation for antimalarial therapies.Natural artemisinin is unique to the traditional Chinese medicinal plant Artemisia annua L.,and its content in this plant is low.This has motivated the synthesis of this bioactive compound using yeast,tobacco,and Physcomitrium patens systems.However,the artemisinin production in these heterologous hosts is low and cannot fulfil its increasing clinical demand.Therefore,A.annua plants remain the major source of this bioactive component.Recently,the transcriptional regulatory networks related to artemisinin biosynthesis and glandular trichome formation have been extensively studied in A.annua.Various strategies including(i)enhancing the metabolic flux in artemisinin biosynthetic pathway;(ii)blocking competition branch pathways;(iii)using transcription factors(TFs);(iv)increasing peltate glandular secretory trichome(GST)density;(v)applying exogenous factors;and(vi)phytohormones have been used to improve artemisinin yields.Here we summarize recent scientific advances and achievements in artemisinin metabolic engineering,and discuss prospects in the development of high-artemisinin yielding A.annua varieties.This review provides new insights into revealing the transcriptional regulatory networks of other high-value plant-derived natural compounds(e.g.,taxol,vinblastine,and camptothecin),as well as glandular trichome formation.It is also helpful for the researchers who intend to promote natural compounds production in other plants species.

Yongpeng Li、Yinkai Yang、Ling Li、Kexuan Tang、Xiaolong Hao、Guoyin Kai

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Zhejiang Provincial TCM Key Laboratory of Chinese Medicine Resource Innovation and Transformation,Zhejiang International Science and Technology Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health,Jinhua Academy,School of Pharmaceutical Sciences,Academy of Chinese Medical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China

Frontiers Science Center for Transformative Molecules,Joint International Research Laboratory of Metabolic and Developmental Sciences,Plant Biotechnology Research Center,Fudan-SJTU-Nottingham Plant Biotechnology R&D Center,School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China

国家重点研发计划国家自然科学基金国家自然科学基金浙江省自然科学基金National'Tenthousand Talents Program'for Leading Talents of Science and Technology Innovation in ChinaNational Young Qihuang Scholars Training Program,Innovative Leading Talents Program for Zhejiang Provincial UniversitiesMajor Science and Technology Projects of Breeding New Varieties of Agriculture in Zhejiang ProvinceKey Project at Central Government Level:The Ability Establishment of Sustainable Use for Valuable Chinese Medicine ResourcesResearch Project of Zhejiang Chinese Medical UniversityResearch Project of Zhejiang Chinese Medical UniversityResearch Project of Zhejiang Chinese Medical University中国博士后科学基金

2023YFC35039008200388982304651LQ21H2800042021C0207420603022021JKZDZC062022RCZXZK232023JKZKTS082022M722851

2024

10.1093/hr/uhad292

园艺研究(英文)

园艺研究(英文)

CSTPCD
ISSN：
年,卷(期)：2024.11(2)
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