In order to develop a novel analgesic and anti-inflammatory formulation,compound lidocaine enrofloxacin gel was prepared,the contents of lidocaine hydrochloride and enrofloxacin were determined by high performance liquid chromatography(HPLC),the preliminary stability test was carried out,and the clinical effect of the gel was preliminarily evaluated through the in vitro antibacterial test of canine natural wound infection model and the analgesic effect test of canine body surface trauma modeling.The results show that:The contents of lidocaine and enrofloxacin in the compound gel prepared by the prescription process met the requirements;The products met the requirements in high temperature,high humidity,strong light tests and 6-month accelerated test results;Antibacterial effect test showed when the enrofloxacin contentdiluted to as low as 0.01%,the antibacterial effect was still good;Body surface trauma modeling results showed that the analgesic onset time of compound gel(3.67 min)was faster than the control group(4.67 min),and the analgesic effect was better than the control group(33.33%had mild pain reaction).In conclusion,the prescription and preparation process of the compound lidocaine enrofloxacin gel are feasible,the product has stable properties,and the in vitro antibacterial effect is good,it is effective for wound analgesia on dogs.
国家科技期刊平台
NSTL
维普
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