In the pathogenesis of African Swine Fever(ASF)caused by the African Swine Fever Virus(ASFV),inflammatory factors play a crucial role,leading to a highly contagious and severe hemorrhagic disease.In this study,the I10L protein of ASFV is identified as a potential inhibitor of the NF-κB signaling pathway triggered by TNF-α and IL-1β.Ectopically expressed pI10L significantly inhibits the activation of the NF-κB signaling pathway in HEK293T and PK-15 cells.The ASFV mutant lacking the I10L gene(ASFVΔI10L)induces higher levels of inflammatory factors in primary porcine alveolar macrophages(PAMs)compared to its parental ASFV HLJ/2018 strain(ASFVWT).This study elucidates the immunomodulatory activity of pI10L and provides insights for a deeper understanding of ASFV pathobiology and the development of vaccines against ASF.
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