金枪鱼共附生菌Streptomyces sp.TUN21的次级代谢产物研究
Study on Secondary Metabolites of Tuna-associated Streptomyces sp.TUN21
余磊1
作者信息
- 1. 浙江省舟山市农产品质量安全管理中心,浙江 舟山 316022
- 折叠
摘要
海洋动物共附生微生物次级代谢产物是海洋药物的重要来源.该文从金枪鱼共附生菌Streptomyces sp.TUN21的次级代谢产物中分离得到3个化合物,分别为campechic acid B(1),5-(3'-aminophenyl)-2,4-pentadienoic acid(2)和benzenemethanol(3).其中化合物1对PC-3和HCT-116的抑制活性的IC50值分别为(1.3±0.2)μmol和(0.64±0.1)μmol,而化合物2是首次从该属中分离得到的天然产物.化合物1～3在50 μg/mL的浓度下对耐甲氧金黄色葡萄球菌、大肠杆菌和白色念珠菌无抑制活性.
Abstract
Secondary metabolites of Marine animals-associated microorganisms are important sources of marine drugs.In this study,three compounds were isolated from Streptomyces sp.TUN21,They are campechic acid B(1),5-(3'-aminophenyl)-2,4-pentadienoic acid(2)and benzenemethanol(3)respectively.Among them,compound 1 showed inhibitory activity against PC-3 and HCT-116 with IC50 values of(1.3±0.2)μmol and(0.64±0.1)μmol,respectively,while compound 2 was the first natural product isolated from this genus.Compounds 1-3 showed no inhibitory activity against methicillin-resistant Staphylococcus aureus,Escherichia coli,and Candida albicans at a concentration of 50 μg/mL.
关键词
金枪鱼共附生菌/Streptomyces/sp./抗肿瘤活性/抗微生物活性Key words
marine-derived actinomycetes/Streptomyces sp./antitumor activity/antimicrobial activity引用本文复制引用
基金项目
金枪鱼加工副产物制备生物饲料的关键技术研究(2022C31002)
出版年
2024
国家科技期刊平台
NSTL
万方数据