Effects of Tea Tree Oil Extract on Proliferation,Apoptosis and Cycle of Lewis Cells in Mice
To investigate the effect of Tea Tree Oil Extract on the proliferation,apoptosis,and cell cycle of Lewis Lung Cancer Cells.Lewis cells were treated with 6 kinds of tea tree oil extracts with different concentrations(0.1%,0.05%,0.01%).Cell proliferation was detected by MTT method,and cell apoptosis and cycle were detected by flow cytometry.Compared with the control group,6 kinds of tea tree oil extracts at different concentrations had significant inhibitory effects on the proliferation of Lewis cells in mice(P＜0.05 or P＜0.01).The inhibitory effects of 6 kinds of tea tree oil extracts on lung cancer cells were as follows:extracts 2,5,6,4,1,3.Compared with the control group,different concentrations of tea tree oil extract 2 significantly increased the apoptosis rate of Lewis cells(P＜0.05 or P＜0.01),and the proportion of G2/M phase cells was increased(P＜0.01).Tea tree oil extracts can inhibit the proliferation of Lewis Lung Cancer cells,promote the apoptosis of Lewis Lung Cancer cells,and induce cell cycle arrest,and such effect is significantly enhanced with the increase in concentration.
tea tree oilLewis Lung Cancer cellsproliferationapoptosiscell cycle
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