Research Progress on Common Haplotype Genetic Defects in Holstein Cows
Genomic selection technology has significantly facilitated genetic improvement in Holstein cows,yet the issue of inbreeding has accentuated the problem of genetic defects.The accumulation of genomic SNP data has enabled the identification of a variety of haplotype genetic defects,including HH1 to HH7 and the recently discovered MW.The restricted selection of breeding bulls and the extensive use of artificial insemination have led to a narrowing gene pool in dairy cows,accelerating the pace of inbreeding and increasing the likelihood of homozygosity for defect genes,thereby elevating the risk of early embryonic death and congenital defects in calves.Thus,scientific selection and mating measures,along with the utilization of genomic information to gradually eliminate carriers of genetic defect genes,are of paramount importance.This article aims to review the types,pathogenesis,detection methods,impacts on production,and economic losses of genetic defects in Holstein cows.It also anticipates the management and prospects of defective genes in breeding.
国家科技期刊平台
NSTL
万方数据
