首页|A double-edged sword:ROS related therapies in the treatment of psoriasis

A double-edged sword:ROS related therapies in the treatment of psoriasis

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In the onset and progression of psoriasis,redox imbalance is a vital factor.It's widely accepted that too much reactive oxygen species(ROS)always make psoriasis worse.Recent research,however,has shown that the accumulation of ROS is not entirely detrimental,as it helps reduce psoriasis lesions by inhibiting epidermal proliferation and keratinocyte death.As a result,ROS appears to have two opposing effects on the treatment of psoriasis.In this review,the current ROS-related therapies for psoriasis,including basic and clinical research,are presented.Additionally,the design and therapeutic benefits of various drug delivery systems and therapeutic approaches are examined,and a potential balance between anti-oxidative stress and ROS accumulation is also trying to be investigated.

PsoriasisROS related therapiesAntioxidantROS accumulation

Jingyi Hu、Qiong Bian、Xiaolu Ma、Yihua Xu、Jianqing Gao

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Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China

College of Pharmacy,Inner Mongolia Medical University,Hohhot 010000,China

Jiangsu Engineering Research Center for New-type External and Transdermal Preparations,Changzhou 213149,China

2022

亚洲药物制剂科学(英文版)
沈阳药科大学

亚洲药物制剂科学(英文版)

SCI
ISSN：1818-0876
年,卷(期)：2022.17(6)
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