Development of biomedical hydrogels for rheumatoid arthritis treatment

扫码查看

原文链接

万方数据
维普

外文摘要：Rheumatoid Arthritis(RA)is an autoimmune disorder that hinders the normal functioning of bones and joints and reduces the quality of human life.Every year,millions of people are diagnosed with RA worldwide,particularly among elderly individuals and women.Therefore,there is a global need to develop new biomaterials,medicines and therapeutic methods for treating RA.This will improve the Healthcare Access and Quality Index and also relieve administrative and financial burdens on healthcare service providers at a global scale.Hydrogels are soft and cross-linked polymeric materials that can store a chunk of fluids,drugs and biomolecules for hydration and therapeutic applications.Hydrogels are biocompatible and exhibit excellent mechanical properties,such as providing elastic cushions to articulating joints by mimicking the natural synovial fluid.Hence,hydrogels create a natural biological environment within the synovial cavity to reduce autoimmune reactions and friction.Hydrogels also lubricate the articulating joint surfaces to prevent degradation of synovial surfaces of bones and cartilage,thus exhibiting high potential for treating RA.This work reviews the progress in injectable and implantable hydrogels,synthesis methods,types of drugs,advantages and challenges.Additionally,it discusses the role of hydrogels in targeted drug delivery,mechanistic behaviour and tribological performance for RA treatment.

外文关键词：

Rheumatoid arthritisOrthopeadic jointsHydrogelTherapeuticsMechanical propertiesMedicine

作者：

Mirza Muhammad Faran Ashraf Baig、Lee Ki Wong、Abdul Wasy Zia、Hongkai Wu

展开 >

作者单位：

Department of Chemistry,Hong Kong University of Science and Technology,Hong Kong 999077,China

Institute of Mechanical,Process and Energy Engineering(IMPEE),School of Engineering and Physical Sciences,Heriot-Watt University,Edinburgh,United Kingdom

基金：

Shenzhen Science and Technology Innovation Committee(SZSTI)Guang Dong Basic and Applied Basic Research FoundationHong Kong Research Grant Council(RGC)funding projectsHong Kong Research Grant Council(RGC)funding projectsHong Kong Research Grant Council(RGC)funding projectsHong Kong Innovation and Technology Commission(HKITC)funding project

项目编号：

SZ-SZSTI20102022B1515130010GRF16308818GRF16309920GRF16309421MHP/003/19

出版年：

2024

DOI：

10.1016/j.ajps.2024.100887

亚洲药物制剂科学(英文版)

沈阳药科大学

亚洲药物制剂科学(英文版)

ISSN：1818-0876

年,卷(期)：2024.19(1)