首页|Recent progress of ferroptosis in cancers and drug discovery

Recent progress of ferroptosis in cancers and drug discovery

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Ferroptosis is a nonapoptotic form of cell death characterized by iron dependence and lipid peroxidation.Ferroptosis is involved in a range of pathological processes,such as cancer.Many studies have confirmed that ferroptosis plays an essential role in inhibiting cancer cell proliferation.In addition,a series of small-molecule compounds have been developed,including erastin,RSL3,and FIN56,which can be used as ferroptosis inducers.The combination of ferroptosis inducers with anticancer drugs can produce a significant synergistic effect in cancer treatment,and patients treated with these combinations exhibit a better prognosis than patients receiving traditional therapy.Therefore,a thorough understanding of the roles of ferroptosis in cancer is of great significance for the treatment of cancer.This review mainly elaborates the molecular biological characteristics and mechanism of ferroptosis,summarizes the function of ferroptosis in cancer development and treatment,illustrates the application of ferroptosis in patient's prognosis prediction and drug discovery,and discusses the prospects of targeting ferroptosis.

FerroptosisCancerDrugTreatment

Xiang Wang、Xinxin Ren、Xu Lin、Qi Li、Yingqiong Zhang、Jun Deng、Binxin Chen、Guoqing Ru、Ying Luo、Nengming Lin

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Department of Pharmacy,Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province,Affiliated Hangzhou First People's Hospital,School of Medicine,Westlake University,Hangzhou 310006,China

Department of Pathology,Zhejiang Provincial People's Hospital(Affiliated People's Hospital,Hangzhou Medical College),Hangzhou 310014,China

Key Laboratory of Endocrine Gland Diseases of Zhejiang Province,Zhejiang Provincial People's Hospital(Affiliated People's Hospital,Hangzhou Medical College),Hangzhou 310014,China

Clinical Research Center for Cancer of Zhejiang Province,Zhejiang Provincial People's Hospital(Affiliated People's Hospital,Hangzhou Medical College),Hangzhou 310014,China

Department of Thoracic Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China

Cancer Center,Zhejiang University,Hangzhou 310058,China

Westlake Laboratory of Life Sciences and Biomedicine of Zhejiang Province,Hangzhou 310024,China

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2024

10.1016/j.ajps.2024.100939

亚洲药物制剂科学(英文版)
沈阳药科大学

亚洲药物制剂科学(英文版)

ISSN：1818-0876
年,卷(期)：2024.19(4)