首页|Design strategies,advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease
Design strategies,advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
Inflammatory bowel diseases(IBD)significantly contribute to high mortality globally and negatively affect patients'qualifications of life.The gastrointestinal tract has unique anatomical characteristics and physiological environment limitations.Moreover,certain natural or synthetic anti-inflammatory drugs are associated with poor targeting,low drug accumulation at the lesion site,and other side effects,hindering them from exerting their therapeutic effects.Colon-targeted drug delivery systems represent attractive alternatives as novel carriers for IBD treatment.This review mainly discusses the treatment status of IBD,obstacles to drug delivery,design strategies of colon-targeted delivery systems,and perspectives on the existing complementary therapies.Moreover,based on recent reports,we summarized the therapeutic mechanism of colon-targeted drug delivery.Finally,we addressed the challenges and future directions to facilitate the exploitation of advanced nanomedicine for IBD therapy.
Colon-targeted drug delivery systemInflammatory bowel diseaseDesign strategyTreatment mechanismAdvanced complementary therapy
Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China
School of Traditional Chinese Material,Shenyang Pharmaceutical University,Shenyang 110016,China
NETL
NSTL
万方数据
