Recent advances in copper homeostasis-involved tumor theranostics

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外文摘要：As the third essential trace element in the human body,copper plays a crucial role in various physiological processes,which lays the foundation for its broad applications in cancer treatments.The overview of copper,including pharmacokinetics,signaling pathways,and homeostasis dysregulation,is hereby discussed.Additionally,cuproptosis,as a newly proposed cell death mechanism associated with copper accumulation,is analyzed and further developed for efficient cancer treatment.Different forms of Cu-based nanoparticles and their advantages,as well as limiting factors,are introduced.Moreover,the unique characteristics of Cu-based nanoparticles give rise to their applications in various imaging modalities.In addition,Cu-based nanomaterials are featured by their excellent photothermal property and ROS-associated tumor-killing potential,which are widely explored in diverse cancer therapies and combined therapies.Reducing the concentration of Cu2+/Cu+is another cancer-killing method,and chelators can meet this need.More importantly,challenges and future prospects are identified for further research.

外文关键词：

Copper homeostasisTumor theranosticsCu-based nanoparticlesCuproptosisChelators

作者：

Xinghua Ren、Xinyi Luo、Fuchang Wang、Long Wan、Xiaofan Wang、Jinya Xiong、Mengwei Ye、Shiqiao Rui、Zhu Liu、Siling Wang、Qinfu Zhao

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作者单位：

Department of Pharmaceutics,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China

Wuya College of innovation,Shenyang Pharmaceutical University,Shenyang 110016,China

Department of Pharmacy,The First Hospital of China Medical University,Shenyang 110001,China

School of Pharmacy,China Medical University,Shenyang 110122,China

Department of Pharmacy,The Fourth Affiliated Hospital of China Medical University,Shenyang 110001,China

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出版年：

2024

DOI：

10.1016/j.ajps.2024.100948

亚洲药物制剂科学(英文版)

沈阳药科大学

亚洲药物制剂科学(英文版)

ISSN：1818-0876

年,卷(期)：2024.19(5)