Extracellular vesicle-functionalized bioactive scaffolds for bone regeneration

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外文摘要：The clinical need for effective bone regeneration in compromised conditions continues to drive demand for innovative solutions.Among emerging strategies,extracellular vesicles(EVs)have shown promise as an acellular approach for bone regeneration.However,their efficacy is hindered by rapid sequestration and clearance when administered via bolus injection.To address this challenge,EV-functionalized scaffolds have recently been proposed as an alternative delivery strategy to enhance EV retention and subsequent healing efficacy.This review aims to consolidate recent advancements in the development of EV-functionalized scaffolds for augmenting bone regeneration.It explores various sources of EVs and different strategies for integrating them into biomaterials.Furthermore,the mechanisms underlying their therapeutic effects in bone regeneration are elucidated.Current limitations in clinical translation and perspectives on the design of more efficient EVs for improved therapeutic efficacy are also presented.Overall,this review can provide inspiration for the development of novel EV-assisted grafts with superior bone regeneration potential.

外文关键词：

Extracellular vesiclesExosomesBiomaterialsLocal deliveryBone regeneration

作者：

Taozhao Yu、Irene Shuping Zhao、Hongguang Pan、Jianhua Yang、Huanan Wang、Yongqiang Deng、Yang Zhang

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作者单位：

School of Dentistry,Shenzhen University Medical School,Shenzhen 518015,China

School of Biomedical Engineering,Shenzhen University Medical School,Shenzhen 518015,China

Institute of Stomatological Research,Shenzhen University,Shenzhen 518055,China

Department of Otolaryngology,Shenzhen Children Hospital,Shenzhen 518034,China

Longgang District People's Hospital of Shenzhen & The Second Affiliated Hospital,The Chinese University of Hong Kong,Shenzhen 518172,China

Key State Laboratory of Fine Chemicals,School of Bioengineering,Dalian University of Technology,Dalian 116024,China

Department of Stomatology,Shenzhen University General Hospital,Shenzhen University,Shenzhen 518055,China

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出版年：

2024

DOI：

10.1016/j.ajps.2024.100945

亚洲药物制剂科学(英文版)

沈阳药科大学

亚洲药物制剂科学(英文版)

ISSN：1818-0876

年,卷(期)：2024.19(5)