Deep near infrared light-excited stable synergistic photodynamic and photothermal therapies based on P-IR890 nano-photosensitizer constructed via a non-cyanine dye

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外文摘要：The cyanine dyes represented by IR780 can achieve synergistic photodynamic therapy(PDT)and photothermal therapy(PTT)under the stimulation of near-infrared(NIR)light(commonly 808 nm).Unfortunately,the stability of NIR-excited cyanine dyes is not satisfactory.These cyanine dyes can be attacked by self-generated reactive oxygen species(ROS)during PDT processes,resulting in structural damage and rapid degradation,which is fatal for phototherapy.To address this issue,a novel non-cyanine dye(IR890)was elaborately designed and synthesized by our team.The maximum absorption wavelength of IR890 was located in the deep NIR region(ca.890 nm),which was beneficial for further improving tissue penetration depth.Importantly,IR890 exhibited good stability when continuously illuminated by deep NIR light.To improve the hydrophilicity and biocompatibility,the hydrophobic IR890 dye was grafted onto the side chain of hydrophilic polymer(POEGMA-b-PGMA-g-C≡CH)via click chemistry.Then,the synthesized POEGMA-b-PGMA-g-IR890 amphiphilic polymer was utilized to prepare P-IR890 nano-photosensitizer via self-assembly method.Under irradiation with deep NIR light(850 nm,0.5 W/cm2,10 min),the dye degradation rate of P-IR890 was less than 5％.However,IR780 was almost completely degraded with the same light output power density and irradiation duration.In addition,P-IR890 could stably generate a large number of ROS and heat at the same time.It was rarely reported that the stable synergistic combination therapy of PDT and PTT could be efficiently performed by a single photosensitizer via irradiation with deep NIR light.P-IR890 exhibited favorable anti-tumor outcomes through apoptosis pathway.Therefore,the P-IR890 could provide a new insight into the design of photosensitizers and new opportunities for synergistic combination therapy of PDT and PTT.

外文关键词：

Photodynamic therapyPhotothermal therapyIR780Non-cyanine dyeDeep near infrared light

作者：

Dawei Jiang、Chao Chen、Peng Dai、Caiyan Li、Zhiyi Feng、Na Dong、Fenzan Wu、Junpeng Xu、Ping Wu、Liuxi Chu、Shengcun Li、Xiaokun Li、Youjun Yang、Weian Zhang、Zhouguang Wang

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作者单位：

Affiliated Cixi Hospital,Wenzhou Medical University,Ningbo 325300,China

Shanghai Key Laboratory of Functional Materials Chemistry,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China

School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou 325000,China

Oujiang Laboratory,Zhejiang Lab for Regenerative Medicine,Vision and Brain Health,School of Pharmaceutical Science,Wenzhou 325000,China

Institute for Environmental Pollution and Health,School of Environmental and Chemical Engineering,Shanghai University,Shanghai 200444,China

Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China

Rehabilitation Medicine Center,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou 325000,China

National Key laboratory of macromolecular drug development and manufacturing,School of Pharmaceutical Science,Wenzhou Medical University 325035,China

State Key Laboratory of Bioreactor Engineering,Biomedical Nanotechnology Center,Shanghai Collaborative Innovation Center for Biomanufacturing Technology,School of Biotechnology,East China University of Science and Technology,Shanghai 200237,China

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出版年：

2024

DOI：

10.1016/j.ajps.2024.100955

亚洲药物制剂科学(英文版)

沈阳药科大学

亚洲药物制剂科学(英文版)

ISSN：1818-0876

年,卷(期)：2024.19(5)