首页|Neutrophil-targeted liposomal platform:A shift in novel approach for early detection and treatment of cancer metastasis
Neutrophil-targeted liposomal platform:A shift in novel approach for early detection and treatment of cancer metastasis
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Tumor metastasis is responsible for 90％of cancer-associated deaths,and its early detection may decrease the likelihood of mortality.Studies have demonstrated that metastasis results from the interaction between"seeds"(tumor cells)and"soil"(pre-metastatic niche,PMN).As the first and most abundant immune cells to be recruited to PMN,neutrophils play a key role in the ultimate formation of metastatic foci through mechanisms such as supporting tumor cell growth,promoting angiogenesis,and shaping an immune-suppressive microenvironment.In this study,two distinct types of sialic acid(SA)-modified liposomes were prepared to target and regulate pro-metastatic neutrophils through the 1-selectin receptor.One of these liposomes,named ICG@SAL,was used to encapsulate indocyanine green(ICG)and was specifically designed for the early detection of cancer metastasis.The other liposome,referred to as ABE/Cur@SAL,co-loaded abemaciclib(ABE)and curcumin(Cur),with the intention of suppressing the progression of metastatic tumor.Fluorescence imaging results from the mouse spontaneous metastasis model indicated that ICG@SAL demonstrated faster targeting and stronger accumulation in the metastatic organs than unmodified ICG liposomes(ICG@CL).This suggested that ICG@SAL could detect tumor metastasis at an early stage.The therapy with co-loaded liposomes in the mouse experimental lung metastasis model indicated that ABE/Cur@SAL could inhibit regulatory T(Treg)cell proliferation,enhance effector T cell activity and reduce tumorigenic factor release,implying that ABE/Cur@SAL could inhibit tumor metastasis.Overall,our work provided a sensitive and convenient approach to early diagnosis and treatment of tumor metastasis.ICG@SAL could be employed for the early detection of tumor metastasis,while ABE/Cur@SAL could be used to inhibit the development of tumor metastasis when early metastasis was identified.
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