Modern intelligent manufacturing automotive enterprises are committed to make full use of 5G,artificial intelligence,big data,cloud computing,Internet,mobile Internet and other modern communication information technology,achieve optimizations such as 5G-enhanced AGV operations,quality feedback in production,and flexible manufacturing processes,5G+flexible production optimization,to build state comprehensive perception,information efficient flexible processing,convenient application optimization of intelligent industrial manufacturing platform,gradually realize enterprise transformation from automation production to intelligent production.This paper analyzes the network security risks faced by the 5G+AI-based automobile intelligent manufacturing industrial park,puts forward the end-to-end network security guarantee scheme,and develops a comprehensive information security system for 5G+AI-enabled intelligent automotive manufacturing,covering network security,system and platform security,business and data security,management and operation and maintenance security.