重庆地区192例HIV/HCV合并感染者的回顾性研究
Retrospective analysis of 192 cases of HIV/HCV co-infection in Chongqing
刘敏 1何小庆 1罗亚东 1袁婧 1吴玉珊 1谭顺 1王静 1陈耀凯1
作者信息
- 1. 重庆市公共卫生医疗救治中心,重庆 400036
- 折叠
摘要
目的 分析重庆地区艾滋病病毒(HIV)/丙型肝炎病毒(HCV)合并感染的发生率及危险因素;了解HIV合并慢性HCV感染者HCV-IgG抗体的产生情况,分析部分病人不能产生HCV-IgG的可能危险因素.方法回顾性收集HIV/HCV合并感染者资料,分析合并感染的可能危险因素;统计HIV合并慢性HCV感染者HCV-IgG阴性发生率,分析其HCV-IgG阴性的可能危险因素.结果 3 013例HIV感染者/艾滋病病人中合并HCV感染192例(6.37％);合并感染HCV者的HIV病毒载量[(4.97±0.89)log拷贝/mL]低于单纯HIV感染者[(5.15±0.81)log拷贝/mL](P<0.05);合并感染者中吸毒人数的比例(64.06％)高于单纯HIV感染者(0.92％)(P<0.05).合并感染者中13例(6.77％)HCV-IgG阴性.单因素分析显示,HCV-IgG阴性组较阳性组年龄偏大(P<0.05),HCV-IgG阴性组通过性途径导致感染所占比例(92.31％)高于阳性组(31.84％)(P<0.05);多因素分析显示,通过性途径导致合并感染者出现HCV-IgG阴性的风险,为通过静脉吸毒途径导致感染者的52.669倍.结论 重庆地区HIV/HCV合并感染发生率较高,静脉吸毒是合并感染的高危因素;合并HCV感染可能抑制HIV复制;年龄、传播途径为HIV/HCV合并感染者产生HCV-IgG的危险因素,其中性传播为影响HCV-IgG产生的独立危险因素.
Abstract
Objective To analyze the incidence and risk factors of HIV/HCV co-infection in Chongqing and to understand the status of HCV-IgG antibodies in HIV-positive patients.Risk factors were analyzed esp.among the patients who could not produce HCV-IgG antibodies.Methods Retrospective analysis was made based on the collected clinical data of HIV/HCV co-infected patients followed by the analysis of risk factors, and HCV-IgG negative incidence of HIV/HCV co-infection.Results Among the 3013 HIV-infected patients, 192 (6.4％) were infected with HCV.HIV/HCV co-infected patient (4.97±0.89 log copy/mL) had significantly lower HIV-RNA levels than the pure HIV-infected patients (5.15±0.81 log copy/mL) (P<0.05).The proportion of drug addicts in HIV/HCV co-infection (64.0％) was higher than that in HIV-infected patients (0.92％) (P<0.05).There were 13 cases (6.8％) of HCV-IgG negative in the HIV/HCV co-infected patients.Single factor analysis showed that HCVIgG negative group was older than the positive group (P<0.05), and the proportion of HCV-IgG negative group infected via sexual transmission (92.31％) was significantly higher than that of the positive group (31.84％).Multivariate analysis showed that the risk of HCV-IgG negative in the co-infected group via sexual transmission was52.669 times greater than that by intravenous drug use.Conclusion The incidence of HIV/HCV co-infection in Chongqing is 6.4％, and intravenous drug use is a high risk factor for HIV/HCV co-infection.HCV infection may inhibit the replication of HIV-RNA.Age and route of transmission are risk factors for HCV-IgG in HIV/HCV infected patients, and sexual transmission is an independent risk factor for HCV-IgG.
关键词
艾滋病病毒/丙型肝炎病毒/合并感染/丙型肝炎病毒IgGKey words
HIV/Co-infection/HCV/HCV-IgG引用本文复制引用
基金项目
重庆市卫生计生委医学科研计划项目(2017MSXM119)
出版年
2018
NETL
NSTL
维普
万方数据