Clinical characteristics of 17 cases of HIV with monkeypox virus infection in Beijing
Objective To analyze the clinical manifestations,laboratory tests,and clinical outcomes of HIV cases with monkeypox virus(MPXV)infection in Beijing,and to provide evidence for the clinical diagnosis and treatment of HIV cases with MPXV infection.Methods A retrospective study was conduct of 17 HIV cases with MPXV infection admitted to the Department of Infection and Immunology of Beijing You'an Hospital Affiliated to Capital Medical University,from June to July 2023.The epidemiological characteristics,initial symptoms,clinical manifestations,CD4+T lymphocyte count,HIV viral load,antiretroviral therapy(cART)status and efficacy were retrospectively analyzed.Results All of the 17 cases were men who have sex with men(MSM),with a median age of 30(26,33)years and a median time since onset of 8(5,9)days.Prior to onset,all cases engaged in male homosexual behavior.Only 1 case had been vaccinated against smallpox in childhood,while the other 16 cases had never been vaccinated.The predominant clinical manifestations were rash(17 cases),fever(15 cases),and lymph node enlargement(8 cases).Typical rashes were found on the genitals,limbs,face,trunk,and other areas.Of the 17 cases,15 had received cART and 12 of them for more than 5 years,10 had CD4+T lymphocytes of ≥500/μL,13 had HIV RNA expressions below the lower limit of detection.All 17 cases improved and were discharged after symptomatic treatment.Conclusions Clinical attention must be paid to HIV cases with MPXV,especially those with CD4+T cells less than 200/μL.For effective prevention and treatment of MPXV infection,priority should be given to prophylactic vaccination of HIV-infected individuals and high-risk MSM.In addition,positive health education for HIV-infected individuals who are not on cART and whose CD4+T cells less than 200/uL is also crucial.
万方数据
维普
