Objective This study explores the ability of different tests in identifying latent tuberculosis infection(LTBI)in patients with HIV/AIDS,and provides a scientific and feasible method for efficient identification of LTBI.Methods Recombinant Mycobacterium tuberculosis fusion protein(EC),tuberculin skin test(TST),and γ-interferon release assay(IGRA)were used to screen LTBI in patients with HIV/AIDS.Results of the IGRA were used as the standard to compare the screening effects of TST and EC test.Results A total of 93 individuals infected with HIV/AIDS were screened,with positive rates of 10.8％(10/93)for IGRA,22.6％(21/93)for TST,and 12.9％(12/93)for EC tests.The positive rate of the TST was higher than that of the IGRA(P＜0.05),but no statistical difference was observed in the positive rate of the EC test and that of the IGRA(P＞0.05).In addition,according to the results of the IGRA for detecting latent tuberculosis infection as the standard,the sensitivity of the TST was 60.0％and its specificity was 81.9％.The sensitivity of the EC test was 50.0％and its specificity was 91.6％.There was no statistically significant difference between the two tests in terms of sensitivity,while the EC test exhibited a higher specificity than the TST.Further,both the TST and EC tests had a Kappa value of 0.527,displaying medium conformity.The positive rate of the EC test reflects the prevalence of LTBI among patients with HIV/AIDS more accurately compared with the TST,and the specificity of EC test was also better than that of the TST.Conclusions EC test is easier to conduct,and screening for LTBI in the HIV/AIDS population using an EC test has certain application value.
维普
万方数据